Friday, 21 October 2016

Does the world have too many HiSeq X Tens?

Illumina stock dropped 25% after a hammering by the stock market with their recent announcements that Q3 revenues would be 3.4% lower than expected at just $607 million. This makes Illumina a much more attractive acquisition (although I doubt this summers rumours of a Thermo bid had any substance), and also makes a lot of people ask the question "why?"

The reasons given for the shortfall were "a larger than anticipated year-over-year decline in high-throughput sequencing instruments" i.e. Illumina sold fewer sequencers than it expected to. It is difficult to turn these revenue figures and statements into the number of HiSeq 2500's, 4000's or X's that Illumina missed it's internal forecasts by, but according to Francis de Souza Illumina "closed one less X deal than anticipated" - although he did not say if this was an X5, X10 or X30! Perhaps more telling was that de Souza was quoted saying that "[Illumina was not counting on a continuing increase in new sequencer sales]"...so is the market full to bursting?



Before diving into my own analysis (you might also like to read GenomeWeb's coverage), I would like to put these numbers in perspective. A 3rd quarter revenue of $607 million is nearly $2.5 billion over the full year (versus $2.3B in 2016 and $2.1B in 2015 (numbers from Illumina data here). And revenues grew by 10% year on year. This does not seem like bad news from an academic users perspective!

Is there such a thing as too many sequencers: Illumina have talked about how they were surprised by the interest in X Ten, and have sold far more units than they initially forecast. The word on the street seems to be that only a few X Ten labs are working at capacity Broad, NYGC, Human Longevity. Illumina have said the reagent pull-though on X Ten has been about $650K/X/year, which is only half of the theoretical $1.2 million/X/year.

Sales of HiSeq 4000 appear not to have been as strong as the 2500 platform was on its launch. NextSeq seems to be popular with almost 1000 units out in the field, especially for NIPT use, but also in medium sized labs wanting their own sequencer. I suspect a fair number of MiniSeq's are rolling off the production line (although whether they offer good value for money is debatable).

But Illumina's main reasons for slightly lower than expected performance were clearly lower sales of instruments; and this was particularly so in Europe last quarter. Todd Campbell at The Motley Fool asked an important question about what's happening in Europe "Europe was [growing] slower than the rest of the world." but he also poseed the questions "Why? What's so special about Europe? What are the things that could be going into the reasoning behind Europe growing more slowly than the other parts of the world?" He went on to discuss competition (from Oxford Nanopore) as being a factor, but most telling was something he picked up on from the Illumina conference call when their results were announced at the end of Q2 "Europe is slowing is because of sharing of devices"!

I'd wholly subscribe to the "glut of capacity and increased use of outsourcing" hypothesis. If the glut does not go away, and if labs continue to move to outsourcing then Illumina will sell decreasing numbers of instruments and service contracts, but consumables pull-through should be higher from each box. Ultimately I think this is a win for Illumina as more science will be published using their technology - and that's really what we all want.



I run a core lab, and I know lots of other people who do in Europe, Africa, and across the world. Sharing Illumina (and other) instruments in core labs has been a part of science for a very long time. It makes good sense scientifically and economically (I know I'm biased). And from where I sit I can see many Illumina sequencers gathering dust (metaphorically speaking), or being run at 25% or lower utilisation. People got the funding to buy these amazing devices; but not the money to staff the lab, to service them, and to fund the projects to run on them. Perhaps worse is the opportunity cost of the lost science; science that could not be done because someone spent money on a sequencer rather than sequences.


Maybe instrument sales have slowed down in Europe because we've got wise to this problem, maybe scientists in Europe have seen how great great core labs can be, and that shared devices with high utilisation is a good thing for science in general. But what happens, if I'm right, when the rest of the world realises it has too many sequencers but not as many results as they'd expected, and focuses on buying sequences rather than sequencers?

Will users continue to purchase consumables at an ever increasing rate: Illumina's business model has been described as "a simple razor and blade model: Illumina makes one-time sales of large machines at lower margins, then provides consumables needed for use in their operation on an ongoing basis."

A Tweet earlier in the year from Kinghorn Genomics is one of the few public figures I've seen for actual sequencing throughput on an X Ten. 1100 genomes in one month is astounding, but still 20-30% short of the 1500 per month figure in Illumina's specs. Very few owners openly discuss the numbers of samples going through their instruments, and Illumina are very cagey about reagent pull-through in individual labs. It seems pretty clear if X Ten labs simply can't pull in the required numbers of samples to match Illumina's specs. But Kinghorn Genomics is at the high end of reagent pull through at < 70% utilisation.


Illumina's consumables are a highly profitable business with gross profits around 70%, and these margins have been at that level for as long as I can remember. I don't want to skip over the fact that Illumina has also invested heavily in R&D, and is investing heavily in the clinical adoption of it's core technology in the clinical space via Helix and Grail. So some of that 70% margin is going somewhere that is likely to be useful to me in the future. But lllumina have cited weakness in the HiSeq franchise outside of the X – both instrument shipments and consumables. Regent pull-through on HiSeq was below their estimates of ~$350K per year. Again pointing to a glut of sequencers, rather than sequencing projects. So reagents are perhaps the most important thing for Illumina to focus on.

  • Total revenue increased by $93.9 million to $1,171.9 million in the first half of 2016; up by 9% over 2015.
  • Consumables revenue (63% of total) increased by $128.4 million to $740.1 million in the first half of 2016; up by 21% over 2015 "driven by growth in the sequencing instrument installed base".
  • Instrument revenue (20% of total) decreased by $58.5 million to $243.2 million in the first half of 2016; down by 19% over 2015 "primarily due to lower shipments of our high-throughput platforms".
  • Service and other revenue (15% of total) increased by $23.2 million to $179.2 million in the first half of 2016; up by 15% over 2015 "driven by revenue from genotyping services and extended instrument service contracts associated with a larger sequencing installed base".

What locks us into Illumina: Capital costs are very high in replacing an Illumina fleet, my own lab has around £2 million invested (2x HiSeq 4000, 1x HiSeq 2500, 1x NextSeq, 2x MiSeq) - we couldn't simply go out and buy machines from another vendor, even if there were one. The real tie in is the infrastructure we've built up around the use of Illumina sequencing. Users are unlikely to switch until there is a really good competitor out there...and Life Tech's SOLiD and Ion Torrent technologies just were not good enough.

Predicting the future: For the future I'm as confident as everyone else that NGS usage is going up, bigger projects, more samples, more sequencing, more data - that's a great scenario for Illumina. They might be a bit stuck with the next big leap in instrument yields, as this would need to jump significantly to make labs like mine purchase new boxes, and that could land them back in the same position as they were in 2011. If the economic case for a new machine can't be made then labs will find it hard to get funding for incremental changes. And if Illumina do make a big leap then many labs may prefer to share the infrastructure costs, and aim bring down experimental costs. Where do Illumina go in the research space next if they can't bring us cheaper sequencing?



Q: What will Illumina announce at J.P.Morgan? A new sequencer? The $500 genome? Nanopores?


The use of NGS in oncology might take ten years to become profitable given the pace at which healthcare systems can adopt new technologies. I know from my experiences of the NHS that a few labs can be leading lights, but the majority need to be dragged into accepting change of almost any kind. Oncology is tough, but is a huge, and highly profitable, market so the effort from Illumina is likely to be worth it. Illumina certainly think so; SeekingAlpha quoted Francis deSouza (Illumina CEO) as saying "We spent a decade selling instruments to researchers who are experts and understand genomics. Now we're seeing applications take off, which is a much bigger market for us." Whether the recent stock fall was partly because the markets see the realisation of this "bigger market" as being too much of a future gamble is unclear to me. VerinataGrail and Helix are really exciting ventures, but how quickly can they add to Illumina's revenues and profits?

The rapid adoption of NGS in NIPT might shed some light on the future. Verinata is now contributing high single digit percentages to Illumina's revenues, and this could reach 10% as soon as 2018. I'd highly reccomend anyone who can get access to BBC Player to watch the "A world without Downs" documentary!

I thought I'd finish up with a look to the future; particularly to the other NGS technology that we might be using alongside Illumina routinely by 2020 - Oxford Nanopore. The technology, soon to be "a genome centre in a box", and possibly iPhone compatible, is starting to gain traction outside of the hardcore fanboys and fangirls like Nick Loman and Josh Quick. Right now it is certainly an unproven, in the commercial sense; closed-community, the MinION is available commercially, but users are generally talking in the Nanopore forum; and niche tool. But R9 makes Nanopore sequencing easy, and the most recent updates from Clive Brown point to a future where we might use Nanopores alongside SBS. If the ONT tech is truly disruptive then there is a future that may be decidedly less longer orange! 

I'd not want to forget to mention Pacific Bioscience now that Sequel appears to be getting some traction (over 100 instruments sold since the launch compared to 100-150 RSIIs). And the 50x drop in DNA required is going to make this a tool people with limited sample availability can now consider using.


But we should not forget that Illumina is a company that can deliver on innovation. Whilst Illumina did not invent SBS - Solexa, a small UK company, did; Illumina turned Solexa's $2.5 million revenues in 2006, into a $100 million business, in one year! Many readers will remember the release of the HiSeq, MiSeq, NextSeq, X Ten - all significant leaps for genomics; and I'm betting they've got some pretty cool tech up their sleeves yet.

Finally: Do you think there are too many sequencers out there? Should we focus on buying sequences rather than sequencers? If the majority of users answer yes to these questions then sequencer sales may well continue to decline in the short term. But reagent pull-through on each box should increase, and Illumina's focus for research sequencing might shift to "blades rather than razors", on driving utilisation of their instal base up.

39 comments:

  1. We've recently put together a dashboard showing our throughput at SciLifeLab in Stockholm if you're interested: https://ngisweden.scilifelab.se/file/stockholm_dashboard

    This shows output from 5 of our X10 sequencers (the ones based in Stockholm).

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  2. Great piece thanks James. Certainly some good food thought.

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  3. Very interesting article. The key on the consumables will be how proprietary are they, and how soon generic consumables from Thermo Fisher's Life Technologies acquisition can compete on a regular basis.

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  4. Hi James. From someone on Wall Street's perspective, it wasn't the $625M to $607M that people cared about. It was the Q4 number going from $685M to $607M. 10% on the year is great however, you're looking at it from historical perspective. Investors care about it from forward perspective. So Q4 growing at 2.5% implies people have to take 2017 number down and that matters more than 2016 overall growth (which includes Q1, Q2, and Q3).

    Finally the delta of growth matters more given that we are looking at longer term performance (compounding growth) to gauge value.

    For example, We value on 2019 numbers (not on 2016). If growth is accelerating (say from 10% to 13%) 2019 revenue is $3.3B if growth is declining (say from 10% to 7%) 2019 revenue would be $2.9B.

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  5. The price of their consumables is too high - 70% profit seems low to me. If they concentrated on what their installed base actually want to do day to day, then they'd never have a shortfall. If users are sharing flowcells to bring costs down then using a core lab - and their expertise - becomes the smarter choice. More people making that choice means fewer instruments being sold. I've always advised people in the market for capital equipment to look at the price of consumables before taking the plunge. I think more prospective sequencer customers are doing just that.

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    Dr EDOROR Through His Email on dredororcurecenter@gmail.com

    ReplyDelete
  20. Hello, I want to let the general public know of how i got cured from Herpes disease by dr. bello I'm tracy tanny and i am from usa, i was Herpes positive and i was been sustain with medications but i wasn't cured. A friend of mine told me about a man called dr bello and showed me testimonies on how people are talking about how this man cured them from herpes and others from HIV but i never believe it. But after much discussion i tough of giving this man a try, I contacted him with his email and he guided me and told me what to do, now according to what he told me all where true. Now I'm free and happy because Dr. bello has restore me back to normal and happy life by giving me a cure for my Herpes disease and when i went for medical test i was been confirm Herpes negative. So I'm urging you to contact him for help and get cured if you are infected also with any disease or you have any health issues, you can get to him through his email: bellosolutionhom@gmail.com or whatsApp him on +2348147271779

    ReplyDelete
  21. I Am Here Again To Say A Big Thanks To Dr.Sebi For Making Me A Complete woman Again, I Was Infected With Herpes For 5 Years I Have Been Seriously Praying To God And Searching For Cure. I Came Here Last Month To Search For Solution To My Problem And I Saw A Comment Of People Talking About Different Doctors And God Directed Me To Choose Dr.Sebi And I Contacted Him, He Sent Me A Medicine And Directed Me On How I Will Take The Medicine For 7 Days, I Did So And Went For A Test And My Result Came Out As Negative. I Am So Happy, I Shared Tears Of Happiness And I Have Taken It Upon My Self To Always Testify About How God Used Dr.Sebi To Solve My Problem. I Am A Clean woman Now, Without Any Virus If You Are Infected With Any Disease Like HIV AIDS, CANCER ,HERPES Or Any Other Disease You Can Also Be Happy Like Me By Contacting Dr Sebi Through His Email drsebispelltemple@gmail.com or Whatsapp number +2348153863900 or see more at
    http://drsebispelltemple.wixsite.com/spelltemple

    ReplyDelete
  22. The last thing I will ever do is to believe on MEDICAL drugs intense of COPD , I am Anne Chris, New Zealand. I want to appreciate the great work of Dr Abumere, I have been diagnose of COPD for a period of 3years,I’ve lose all hope that there is no cure and I have been taken medicine to sustain myself till I got to know about Dr Abumere through a friend who cured of Chronic obstructive pulmonary . I contacted them by via email>abumereherbalcentre@gmail.com and Medicine sent to me, which I took as prescribed for some period of days and I went to the hospital after consuming the medicine and I was confirmed Negative after 3 years of being positive, it is indeed a miracle honestly,you can contact their email or visit their website on www.abumereherbalcentre.simplesite.com

    ReplyDelete
  23. Good day everyone,I have this great opportunity to share this testimony about how I get cure from my HERPES ,three years ago I was HERPES positive so I was suffering from it I was doing one thing or the order to get a cure there was no way for it so I was on my research on the internet I saw a testimony of a young man, about how dr.peter help him get cured for HERPES with his herbal medicine I was surprise and I do not believe I said okay let me try him I contact him on his email address and he gave me instructions and I follow it he told me what to do and I did it, after a week he sent to me the medicine true DHL he told me how to use it and I did exactly how he instructed me to use it, after two weeks he told me that I should go for test, indeed I did it, and behold I was HERPES "negative" am so grateful Doctor, now am happy with my wife and two kids I want to use this opportunity to say this, please if you have this kind of disease called HERPES , I want you to contact him on is email; dr.peter.herb.solutions@hotmail.com call +2348143044267 and he can also help you get a cure for HPV, CANCER,disease and he can cure you from any kind of diseases with his herbal medicine. all you have to do is to believe him. thank you my Dr may God bless you,dr.peter.herb.solutions@hotmail.com

    ReplyDelete
  24. HELLO OUT THERE.. i quickly want to use this opportunity to explain to you how useful it is to pay attention to any articles that come across your way in life, long time ago i was told by my doctor that There is currently no cure for Herpes Simplex virus. i learnt that Most treatment on herpes focuses on getting rid of sores and limiting outbreaks was made from herbs. It is possible that your sores will disappear without treatment. However, your doctor may determine that you need one or more of the following medications: acyclovir, famciclovir, valacyclovir. These medications may come in oral (pill) form, or may be applied as a cream. For severe outbreaks, these medications may also be administered by injection. However, there are herbal therapies that could totally eradicate this virus from the body meanwhile there has been proofs and lots of testimonies to that effect. I took my time to work with one Dr. Uduebor on and how his herbs magically cured me when I contracted this embarrassing virus. Please do reach out to Dr. Uduebor to cure you the way he did to me now via his email: doctoruduebor@gmail.com or +2347032589678 for call and whatsapp

    ReplyDelete
  25. HELLO OUT THERE.. i quickly want to use this opportunity to explain to you how useful it is to pay attention to any articles that come across your way in life, long time ago i was told by my doctor that There is currently no cure for Herpes Simplex virus. i learnt that Most treatment on herpes focuses on getting rid of sores and limiting outbreaks was made from herbs. It is possible that your sores will disappear without treatment. However, your doctor may determine that you need one or more of the following medications: acyclovir, famciclovir, valacyclovir. These medications may come in oral (pill) form, or may be applied as a cream. For severe outbreaks, these medications may also be administered by injection. However, there are herbal therapies that could totally eradicate this virus from the body meanwhile there has been proofs and lots of testimonies to that effect. I took my time to work with one Dr. Uduebor on and how his herbs magically cured me when I contracted this embarrassing virus. Please do reach out to Dr. Uduebor to cure you the way he did to me now via his email: doctoruduebor@gmail.com or +2347032589678 for call and whatsapp

    ReplyDelete
  26. HELLO OUT THERE.. i quickly want to use this opportunity to explain to you how useful it is to pay attention to any articles that come across your way in life, long time ago i was told by my doctor that There is currently no cure for Herpes Simplex virus. i learnt that Most treatment on herpes focuses on getting rid of sores and limiting outbreaks was made from herbs. It is possible that your sores will disappear without treatment. However, your doctor may determine that you need one or more of the following medications: acyclovir, famciclovir, valacyclovir. These medications may come in oral (pill) form, or may be applied as a cream. For severe outbreaks, these medications may also be administered by injection. However, there are herbal therapies that could totally eradicate this virus from the body meanwhile there has been proofs and lots of testimonies to that effect. I took my time to work with one Dr. Uduebor on and how his herbs magically cured me when I contracted this embarrassing virus. Please do reach out to Dr. Uduebor to cure you the way he did to me now via his email: doctoruduebor@gmail.com or +2347032589678 for call and whatsapp

    ReplyDelete
  27. My Name is Eunice mabel, And this is my Testimony of how i was cured by Dr.Ihibor the great traditional herbal medicine man. I have being seeing series of testimonies and the wonderful work Dr Ihibor has been doing in people lives. This made me contacted him because i have been suffering from herpes virus for a long time now, And When i contacted Dr.Ihibor without wasting time, he told me all i needed to do, and without wasting time i did all he ask of me, So i started taking his medications. And to my greatest surprise within just one month and one weeks i was totally cured and now i am free from any kind of virus I am happy and Glad to say that Dr.Ihibor is really a great and trust worthy man. You can reach him with this Email Address:
    drhopeherbalhome@gmail.com or contact him through whatsapp,Text Message or call:+2349050141449. He said he is also special in curing Any kinds of disease like: HERPES CURE,DIABETES,CANCER,HEPATITIS,HIV/AIDS
    SIPHILIS,EPILEPSY. Or any other disease you are suffering from.

    ReplyDelete
  28. Hi Friends i am so glad to writing this article today to tell the world how my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn't cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr EKIADOLA the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his email: ekiadolaherbalhome@gmail.com i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and suffer when there is someone like Dr EKIADOLA that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact via email: ekiadolaherbalhome@gmail.com call him or whatsapp him on +2349057915075

    ReplyDelete
  29. My name is gavin kate i am from boston usa, you can also add me on
    Facebook or send me an email via gavin000kate@gmail.com
    I am here to give my testimony about
    Dr LUCKY Natural Herbal Medicine who helped me in my
    life, i want to inform the public how i was cured from (HERPES SIMPLEX
    VIRUS) by Dr LUCKY, i visited different hospital but they gave me
    list of drugs like Famvir, Zovirax, and Valtrex which is very expensive
    to treat the symptoms and never cured me. I was browsing through the
    Internet searching for remedy on HERPES and i saw comment of people
    talking about how Dr LUCKY cured them. when i contacted him he gave
    me hope and send a Herbal medicine to me that i took and it seriously
    worked for me, in less than five days i was free, my HERPES result came out negative. I am so happy sharing this testimony. My advice to you all who thinks that there is no cure for Herpes, he is also specialized in the cure of the following: Cancer, HIV, Low sperm count, Barrenness, Hvp, Genital Wart, Rare disease, Hepatitis, Syphilis, Diabetes. etc. just contact him and get cure.
    Dr LUCKY
    EMAIL: Drluckyherbalmedicinehome@gmail.com or doctorkinglucky@gmail.com

    ReplyDelete

  30. All these post about HERBAL MEDICINE and spell caster are scammer and fake
    trying to collect money all in the name of HERPES cure and when you contact
    them, they will be asking for your name, pictures, country, phone number,
    occupation and when you have given them all the information, they will be
    asking for money. my name is AMANDA,a woman of 47years I was once suffering from herpes for good 3years and i spent a
    lot of money going from one herbal doctor to another but they all scam and
    take my money away until i told my friend the problems am facing in life he quickly introduce me to this powerful herbal man called
    Dr.OKOSODO who cured me from Herpes with his herbal medication , after
    Doctor OKOSODO has finished preparing the herbal medicine, he asked me to
    send him my residential address, so that he will send the herbal medicine
    to me via D.H.L so i did. 2days later, i received the herbal medicine and i
    had to follow the instructions he gave to me on how i will apply it. After using if for a week and few days and I noticed that all the symptoms, pain, itch and blisters are gone. 2weeks
    later i went to hospital for test and according to the test done by the
    Medical doctor called Marly it stated that i was herpes negative.
    So viewers be wise and beware of fake people and fake herbal
    doctors, they are all over the internet trying to steal from poor people. I
    will drop the email of this powerful herbal doctor just in case you
    want to contact him for help,EMAIL ON :dr okosodopowerfulhome@gmail.com for more informatio ADD HIS WHASSAPT NO......+2348136623427
    Dr OKOSODO CAN AS WELL CURE THE FOLLOWING DISEASE:-

    1. HERPES
    2. LASSA FEVER
    3. GONORRHEA
    4. HIV/AIDS
    5. LOW SPERM COUNT
    6. MENOPAUSE DISEASE
    7. EPILEPSY
    8. ASEPSIS
    9. CANCER
    10. ANXIETY DEPRESSION
    11. PREGNANCY PROBLEM
    12. SHORT SIGHTEDNESS PROBLEM
    13. ALS
    14. PTSD
    15 ADHD

    ReplyDelete
  31. My name is eunice mabel from usa. I want the world to know
    about the great Dr. Ihibor who cured my hiv/aids.Just when I thought that all hope is gone. God then showed me another way by connecting me to the Great Dr. Ihibor who used herbal medicine to cured my four (4) years hiv/aids. A situation which as also kept me unmarried through out those trouble years. There is no medication I didn't take during those trouble years. I was going through the internet one day when I saw a testimony by one Mrs. Elizabeth on how this great Dr. Ihibor cured she and her husband of hiv/aids. So I decided to contact this great man also, and truly he prepared a herbal medicine for me
    which he instructed me to take within two week. I went for a test immediately I finished taking the herb and the result was Negative. Immediately my heart was field with Joy because I can happily look for my life partner now and get marry. Dr. Ihibor God will bless you, you will leave long. You can also contact this great Dr. Through email drihiborherbalhome@gmail.com OR call him on his
    Phone +2349050141449. You can also add him up on whatsapp +2349050141449

    ReplyDelete
  32. All these post about HERBAL MEDICINE and spell caster are scammer and fake
    trying to collect money all in the name of HERPES cure and when you contact
    them, they will be asking for your name, pictures, country, phone number,
    occupation and when you have given them all the information, they will be
    asking for money. my name is Jame Mary,a woman of 47years I was once suffering from herpes for good 3years and i spent a
    lot of money going from one herbal doctor to another but they all scam and
    take my money away until i told my friend the problems am facing in life he quickly introduce me to this powerful herbal man called
    Dr.ESEZOBOR who cured me from Herpes with his herbal medication , after
    Doctor ESEZOBOR has finished preparing the herbal medicine, he asked me to
    send him my residential address, so that he will send the herbal medicine
    to me via D.H.L so i did. 2days later, i received the herbal medicine and i
    had to follow the instructions he gave to me on how i will apply it. After using if for a week and few days and I noticed that all the symptoms, pain, itch and blisters are gone. 2weeks
    later i went to hospital for test and according to the test done by the
    Medical doctor called Marly it stated that i was herpes negative.
    So viewers be wise and beware of fake people and fake herbal
    doctors, they are all over the internet trying to steal from poor people. I
    will drop the email of this powerful herbal doctor just in case you
    want to contact him for help,EMAIL ON :DRESEZOBORHERBALHOME@GMAIL.COM for more information from me add me on facebook on.....jamemary.......
    Dr ESEZOBOR CAN AS WELL CURE THE FOLLOWING DISEASE:-

    1. HERPES
    2. LASSA FEVER
    3. GONORRHEA
    4. HIV/AIDS
    5. LOW SPERM COUNT
    6. MENOPAUSE DISEASE
    7. EPILEPSY
    8. ASEPSIS
    9. CANCER
    10. ANXIETY DEPRESSION
    11. PREGNANCY PROBLEM
    12. SHORT SIGHTEDNESS PROBLEM
    13. ALS
    14. PTSD
    15 ADHD

    ReplyDelete
  33. I want to share this wonderful testimony to the people all over the world on how i was cured of herpes disease by Dr Ehi. I'm from USA, i was living with herpes for the past two years, just last month as i was browsing on the internet about this deadly disease, i saw a testimony of somebody called Kathy Anne, testifying of how she was cured from herpes by Dr Ehi and i decided to also email this Dr Ehi via ehiherbalhelp@gmail.com and tell him about my problem, he told me to send him some of my personal details which i did and then he prepare the treatments and send them to me. He gave me the instructions on how to use the cure for 14 days and after 7 days, he told me to go for herpes test which i did and to my greatest surprise i was confirmed negative. All thanks be to Dr Ehi and God almighty for curing me of this deadly disease after 2 years and if you know that you have any disease of this kind or any other, email him now via ehiherbalhelp@gmail.com & you can search on google to know more about his cure via https://naturalherbalremedyblog.wordpress.com or +2348143502763 for call and whatsapp and i strongly believe that he will help you just as he did mine.

    ReplyDelete
  34. I used to suffer from HERPES SIMPLEX VIRUS for about 3 years. No medications or treatments ever really did anything for me (i tried them all no one work. but I was actually able to completely cure HERPES naturally after countless hours of online research. What worked for me is as follows: I saw Dr ILLUOBE Information online that he normally cure and treat disease and infirmities with his Herbal Medicine, I never really believed the people who where recommending him thou i saw on blog about 6 people where also testifying on how they were cured by Dr ILLUOBE, and still Ellen recommend Dr ILLUOBE who uses herbal medication to cure HERPES SIMPLEX VIRUS and gave me his email, so i mail him He told me all the things I need to do and also give me instructions to take, which I followed properly.Before I knew what is happening after two weeks the HERPES SIMPLEX VIRUS that was in my body got vanished. so if you are also heart broken and also need a help, you can also email him: drilluobe@live.com. if you are infected with any disease like HIV,AIDS, CANCER,HERPES SIMPLEX VIRUS, or any other disease you can also be happy like me by contacting.....
    Name: Dr.ILLUOBE
    What apps Number: +2348109031502
    Email: drilluobe@live.com
    Website: http://drilluobetemple.webs.com
    I“m given you 100% grantee, soon as you have getting in touch
    with Dr.ILLUOBE your problems will be solved accurately.
    Thanks..

    ReplyDelete

  35. I am so grateful to the great dr idahosa for curing my herpes disease,for 7 years ago i was having this infection that made me look so horrible, since i have been having this disease i have been in a complete agony weeping everyday, i have gone to several places trying to get a cure but nothing was change, i had to search for solution in the internet, luckily i came across this testimony of how Dr idahosa cured a lady from this terrible affection so i decided to contact him through his email address:hsvnaturalremedyclinic@gmail.com i told him exactly how i was feeling and he assure me that he will help me to get cured from my disease, i believed him and obeyed all his instruction that he gave to me, afterwards he prepare a cure for me and when i received it and started using it just as he has promised me, i was cured totally within 2 weeks of usage. contact him at his email; hsvnaturalremedyclinic@gmail.com

    ReplyDelete